The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths
2009
Autori
Brajović, Milan D.Marković, Nataša
Loncar, Goran
Šekularac, Nikola
Kordić, Dejan
Despotović, Nebojsa
Erceg, Predrag
Donfrid, Branislav
Stefanović, Zvezdan
Bajcetić, Milica
Brajović, Ljiljana
Savić, Zivorad
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A group of 72 patients with 111 asymptomatic carotid stenoses (ACS), mean age 65.42 +/- 9.21, and a group of 36 patients with 58 symptomatic carotid stenoses (SCS), mean age 67.63 +/- 8.79, were analyzed prospectively during a 3-year follow-up period. All patients underwent color duplex scan sonography (CDS), carotid arteriography, computed tomography (CT) scan, and neurological examination. The aim of the study was to analyze the correlation between echo plaque morphology (degree and plaque quality), local hemodynamic plaque characteristics, ischemic CT findings, and onset of new neurological events and deaths. The results analysis showed significantly more ACS in the group of 30-49% stenosis (p lt 0.001), but significantly more SCS in the group of 70-89% (p lt 0.0001) and >= 90% stenosis (p lt 0.05). Fibrous plaque was more frequent in the ACS group (p lt 0.001), while ulcerated and mixed plaques were more frequent in the SCS group (both p lt 0.0001). In the SCS group, a significantl...y higher frequency of increased peak systolic and end diastolic velocities was noted at the beginning and end of the study (both p lt 0.01), as well as for contralateral common (CCA) or internal carotid artery (ICA) occlusion ( p lt 0.05 and p lt 0.01, respectively), but reduced carotid blood flow volume (p lt 0.05) only at the end of the study. In the ACS group, the best correlation with new neurological events and deaths was shown with positive CT findings, peak systolic flow velocity over 210 cm/sec, end diastolic flow velocity over 110 cm/sec, plaque stenosis >= 70%, plaque ulceration, mixed plaque (all p lt 0.0001); stenosis >= 50% (p lt 0.001); and reduced carotid blood flow volume (p lt 0.05).
Ključne reči:
carotid stenosis / carotid plaque / cerebrovascular disorders / neurological symptoms / stroke / ultrasonography / angiography / X-ray computed tomography / color duplex scanning / peak flow velocitiesIzvor:
Thescientificworldjournal, 2009, 9, 509-521
DOI: 10.1100/tsw.2009.74
ISSN: 1537-744X
PubMed: 19578708
WoS: 000267630100004
Scopus: 2-s2.0-70349332488
Institucija/grupa
GraFarTY - JOUR AU - Brajović, Milan D. AU - Marković, Nataša AU - Loncar, Goran AU - Šekularac, Nikola AU - Kordić, Dejan AU - Despotović, Nebojsa AU - Erceg, Predrag AU - Donfrid, Branislav AU - Stefanović, Zvezdan AU - Bajcetić, Milica AU - Brajović, Ljiljana AU - Savić, Zivorad PY - 2009 UR - https://grafar.grf.bg.ac.rs/handle/123456789/229 AB - A group of 72 patients with 111 asymptomatic carotid stenoses (ACS), mean age 65.42 +/- 9.21, and a group of 36 patients with 58 symptomatic carotid stenoses (SCS), mean age 67.63 +/- 8.79, were analyzed prospectively during a 3-year follow-up period. All patients underwent color duplex scan sonography (CDS), carotid arteriography, computed tomography (CT) scan, and neurological examination. The aim of the study was to analyze the correlation between echo plaque morphology (degree and plaque quality), local hemodynamic plaque characteristics, ischemic CT findings, and onset of new neurological events and deaths. The results analysis showed significantly more ACS in the group of 30-49% stenosis (p lt 0.001), but significantly more SCS in the group of 70-89% (p lt 0.0001) and >= 90% stenosis (p lt 0.05). Fibrous plaque was more frequent in the ACS group (p lt 0.001), while ulcerated and mixed plaques were more frequent in the SCS group (both p lt 0.0001). In the SCS group, a significantly higher frequency of increased peak systolic and end diastolic velocities was noted at the beginning and end of the study (both p lt 0.01), as well as for contralateral common (CCA) or internal carotid artery (ICA) occlusion ( p lt 0.05 and p lt 0.01, respectively), but reduced carotid blood flow volume (p lt 0.05) only at the end of the study. In the ACS group, the best correlation with new neurological events and deaths was shown with positive CT findings, peak systolic flow velocity over 210 cm/sec, end diastolic flow velocity over 110 cm/sec, plaque stenosis >= 70%, plaque ulceration, mixed plaque (all p lt 0.0001); stenosis >= 50% (p lt 0.001); and reduced carotid blood flow volume (p lt 0.05). T2 - Thescientificworldjournal T1 - The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths EP - 521 SP - 509 VL - 9 DO - 10.1100/tsw.2009.74 ER -
@article{ author = "Brajović, Milan D. and Marković, Nataša and Loncar, Goran and Šekularac, Nikola and Kordić, Dejan and Despotović, Nebojsa and Erceg, Predrag and Donfrid, Branislav and Stefanović, Zvezdan and Bajcetić, Milica and Brajović, Ljiljana and Savić, Zivorad", year = "2009", abstract = "A group of 72 patients with 111 asymptomatic carotid stenoses (ACS), mean age 65.42 +/- 9.21, and a group of 36 patients with 58 symptomatic carotid stenoses (SCS), mean age 67.63 +/- 8.79, were analyzed prospectively during a 3-year follow-up period. All patients underwent color duplex scan sonography (CDS), carotid arteriography, computed tomography (CT) scan, and neurological examination. The aim of the study was to analyze the correlation between echo plaque morphology (degree and plaque quality), local hemodynamic plaque characteristics, ischemic CT findings, and onset of new neurological events and deaths. The results analysis showed significantly more ACS in the group of 30-49% stenosis (p lt 0.001), but significantly more SCS in the group of 70-89% (p lt 0.0001) and >= 90% stenosis (p lt 0.05). Fibrous plaque was more frequent in the ACS group (p lt 0.001), while ulcerated and mixed plaques were more frequent in the SCS group (both p lt 0.0001). In the SCS group, a significantly higher frequency of increased peak systolic and end diastolic velocities was noted at the beginning and end of the study (both p lt 0.01), as well as for contralateral common (CCA) or internal carotid artery (ICA) occlusion ( p lt 0.05 and p lt 0.01, respectively), but reduced carotid blood flow volume (p lt 0.05) only at the end of the study. In the ACS group, the best correlation with new neurological events and deaths was shown with positive CT findings, peak systolic flow velocity over 210 cm/sec, end diastolic flow velocity over 110 cm/sec, plaque stenosis >= 70%, plaque ulceration, mixed plaque (all p lt 0.0001); stenosis >= 50% (p lt 0.001); and reduced carotid blood flow volume (p lt 0.05).", journal = "Thescientificworldjournal", title = "The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths", pages = "521-509", volume = "9", doi = "10.1100/tsw.2009.74" }
Brajović, M. D., Marković, N., Loncar, G., Šekularac, N., Kordić, D., Despotović, N., Erceg, P., Donfrid, B., Stefanović, Z., Bajcetić, M., Brajović, L.,& Savić, Z.. (2009). The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths. in Thescientificworldjournal, 9, 509-521. https://doi.org/10.1100/tsw.2009.74
Brajović MD, Marković N, Loncar G, Šekularac N, Kordić D, Despotović N, Erceg P, Donfrid B, Stefanović Z, Bajcetić M, Brajović L, Savić Z. The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths. in Thescientificworldjournal. 2009;9:509-521. doi:10.1100/tsw.2009.74 .
Brajović, Milan D., Marković, Nataša, Loncar, Goran, Šekularac, Nikola, Kordić, Dejan, Despotović, Nebojsa, Erceg, Predrag, Donfrid, Branislav, Stefanović, Zvezdan, Bajcetić, Milica, Brajović, Ljiljana, Savić, Zivorad, "The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths" in Thescientificworldjournal, 9 (2009):509-521, https://doi.org/10.1100/tsw.2009.74 . .