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The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths

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2009
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Authors
Brajović, Milan D.
Marković, Nataša
Loncar, Goran
Šekularac, Nikola
Kordić, Dejan
Despotović, Nebojsa
Erceg, Predrag
Donfrid, Branislav
Stefanović, Zvezdan
Bajcetić, Milica
Brajović, Ljiljana
Savić, Zivorad
Article (Published version)
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Abstract
A group of 72 patients with 111 asymptomatic carotid stenoses (ACS), mean age 65.42 +/- 9.21, and a group of 36 patients with 58 symptomatic carotid stenoses (SCS), mean age 67.63 +/- 8.79, were analyzed prospectively during a 3-year follow-up period. All patients underwent color duplex scan sonography (CDS), carotid arteriography, computed tomography (CT) scan, and neurological examination. The aim of the study was to analyze the correlation between echo plaque morphology (degree and plaque quality), local hemodynamic plaque characteristics, ischemic CT findings, and onset of new neurological events and deaths. The results analysis showed significantly more ACS in the group of 30-49% stenosis (p lt 0.001), but significantly more SCS in the group of 70-89% (p lt 0.0001) and >= 90% stenosis (p lt 0.05). Fibrous plaque was more frequent in the ACS group (p lt 0.001), while ulcerated and mixed plaques were more frequent in the SCS group (both p lt 0.0001). In the SCS group, a significantl...y higher frequency of increased peak systolic and end diastolic velocities was noted at the beginning and end of the study (both p lt 0.01), as well as for contralateral common (CCA) or internal carotid artery (ICA) occlusion ( p lt 0.05 and p lt 0.01, respectively), but reduced carotid blood flow volume (p lt 0.05) only at the end of the study. In the ACS group, the best correlation with new neurological events and deaths was shown with positive CT findings, peak systolic flow velocity over 210 cm/sec, end diastolic flow velocity over 110 cm/sec, plaque stenosis >= 70%, plaque ulceration, mixed plaque (all p lt 0.0001); stenosis >= 50% (p lt 0.001); and reduced carotid blood flow volume (p lt 0.05).

Keywords:
carotid stenosis / carotid plaque / cerebrovascular disorders / neurological symptoms / stroke / ultrasonography / angiography / X-ray computed tomography / color duplex scanning / peak flow velocities
Source:
Thescientificworldjournal, 2009, 9, 509-521

DOI: 10.1100/tsw.2009.74

ISSN: 1537-744X

PubMed: 19578708

WoS: 000267630100004

Scopus: 2-s2.0-70349332488
[ Google Scholar ]
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6
URI
https://grafar.grf.bg.ac.rs/handle/123456789/229
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  • Катедра за математику, физику и нацртну геометрију
Institution/Community
GraFar
TY  - JOUR
AU  - Brajović, Milan D.
AU  - Marković, Nataša
AU  - Loncar, Goran
AU  - Šekularac, Nikola
AU  - Kordić, Dejan
AU  - Despotović, Nebojsa
AU  - Erceg, Predrag
AU  - Donfrid, Branislav
AU  - Stefanović, Zvezdan
AU  - Bajcetić, Milica
AU  - Brajović, Ljiljana
AU  - Savić, Zivorad
PY  - 2009
UR  - https://grafar.grf.bg.ac.rs/handle/123456789/229
AB  - A group of 72 patients with 111 asymptomatic carotid stenoses (ACS), mean age 65.42 +/- 9.21, and a group of 36 patients with 58 symptomatic carotid stenoses (SCS), mean age 67.63 +/- 8.79, were analyzed prospectively during a 3-year follow-up period. All patients underwent color duplex scan sonography (CDS), carotid arteriography, computed tomography (CT) scan, and neurological examination. The aim of the study was to analyze the correlation between echo plaque morphology (degree and plaque quality), local hemodynamic plaque characteristics, ischemic CT findings, and onset of new neurological events and deaths. The results analysis showed significantly more ACS in the group of 30-49% stenosis (p lt 0.001), but significantly more SCS in the group of 70-89% (p lt 0.0001) and >= 90% stenosis (p lt 0.05). Fibrous plaque was more frequent in the ACS group (p lt 0.001), while ulcerated and mixed plaques were more frequent in the SCS group (both p lt 0.0001). In the SCS group, a significantly higher frequency of increased peak systolic and end diastolic velocities was noted at the beginning and end of the study (both p lt 0.01), as well as for contralateral common (CCA) or internal carotid artery (ICA) occlusion ( p lt 0.05 and p lt 0.01, respectively), but reduced carotid blood flow volume (p lt 0.05) only at the end of the study. In the ACS group, the best correlation with new neurological events and deaths was shown with positive CT findings, peak systolic flow velocity over 210 cm/sec, end diastolic flow velocity over 110 cm/sec, plaque stenosis >= 70%, plaque ulceration, mixed plaque (all p lt 0.0001); stenosis >= 50% (p lt 0.001); and reduced carotid blood flow volume (p lt 0.05).
T2  - Thescientificworldjournal
T1  - The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths
EP  - 521
SP  - 509
VL  - 9
DO  - 10.1100/tsw.2009.74
UR  - conv_1501
ER  - 
@article{
author = "Brajović, Milan D. and Marković, Nataša and Loncar, Goran and Šekularac, Nikola and Kordić, Dejan and Despotović, Nebojsa and Erceg, Predrag and Donfrid, Branislav and Stefanović, Zvezdan and Bajcetić, Milica and Brajović, Ljiljana and Savić, Zivorad",
year = "2009",
abstract = "A group of 72 patients with 111 asymptomatic carotid stenoses (ACS), mean age 65.42 +/- 9.21, and a group of 36 patients with 58 symptomatic carotid stenoses (SCS), mean age 67.63 +/- 8.79, were analyzed prospectively during a 3-year follow-up period. All patients underwent color duplex scan sonography (CDS), carotid arteriography, computed tomography (CT) scan, and neurological examination. The aim of the study was to analyze the correlation between echo plaque morphology (degree and plaque quality), local hemodynamic plaque characteristics, ischemic CT findings, and onset of new neurological events and deaths. The results analysis showed significantly more ACS in the group of 30-49% stenosis (p lt 0.001), but significantly more SCS in the group of 70-89% (p lt 0.0001) and >= 90% stenosis (p lt 0.05). Fibrous plaque was more frequent in the ACS group (p lt 0.001), while ulcerated and mixed plaques were more frequent in the SCS group (both p lt 0.0001). In the SCS group, a significantly higher frequency of increased peak systolic and end diastolic velocities was noted at the beginning and end of the study (both p lt 0.01), as well as for contralateral common (CCA) or internal carotid artery (ICA) occlusion ( p lt 0.05 and p lt 0.01, respectively), but reduced carotid blood flow volume (p lt 0.05) only at the end of the study. In the ACS group, the best correlation with new neurological events and deaths was shown with positive CT findings, peak systolic flow velocity over 210 cm/sec, end diastolic flow velocity over 110 cm/sec, plaque stenosis >= 70%, plaque ulceration, mixed plaque (all p lt 0.0001); stenosis >= 50% (p lt 0.001); and reduced carotid blood flow volume (p lt 0.05).",
journal = "Thescientificworldjournal",
title = "The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths",
pages = "521-509",
volume = "9",
doi = "10.1100/tsw.2009.74",
url = "conv_1501"
}
Brajović, M. D., Marković, N., Loncar, G., Šekularac, N., Kordić, D., Despotović, N., Erceg, P., Donfrid, B., Stefanović, Z., Bajcetić, M., Brajović, L.,& Savić, Z.. (2009). The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths. in Thescientificworldjournal, 9, 509-521.
https://doi.org/10.1100/tsw.2009.74
conv_1501
Brajović MD, Marković N, Loncar G, Šekularac N, Kordić D, Despotović N, Erceg P, Donfrid B, Stefanović Z, Bajcetić M, Brajović L, Savić Z. The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths. in Thescientificworldjournal. 2009;9:509-521.
doi:10.1100/tsw.2009.74
conv_1501 .
Brajović, Milan D., Marković, Nataša, Loncar, Goran, Šekularac, Nikola, Kordić, Dejan, Despotović, Nebojsa, Erceg, Predrag, Donfrid, Branislav, Stefanović, Zvezdan, Bajcetić, Milica, Brajović, Ljiljana, Savić, Zivorad, "The Influence of Various Morphologic and Hemodynamic Carotid Plaque Characteristics on Neurological Events Onset and Deaths" in Thescientificworldjournal, 9 (2009):509-521,
https://doi.org/10.1100/tsw.2009.74 .,
conv_1501 .

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