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dc.creatorSpasojević, Natasa
dc.creatorStanisavljević, Danijela
dc.creatorGavrilović, Ljubica
dc.creatorJovanović, Predrag
dc.creatorČučaković, Aleksandar
dc.creatorDronjak, Slađana
dc.date.accessioned2019-04-19T14:18:19Z
dc.date.available2019-04-19T14:18:19Z
dc.date.issued2012
dc.identifier.issn0172-780X
dc.identifier.urihttp://grafar.grf.bg.ac.rs/handle/123456789/439
dc.description.abstractOBJECTIVES: Right-left asymmetry of human brain function has been known for a century. Brain asymmetry and lateralization has been observed at the neurochemical level. At the neurochemical level, it is important to further correlate changes in monoaminergic activity with the synthesis and reuptake of these monoamines. The aim of the present study was to analyze the effect of social isolation on catecholamine stores as well as on the regulation of catecholamine synthesis and uptake in the right and left hippocampus. METHODS: We examined changes in protein levels of dopamine-beta-hydroxylase (DBH), norepinephrine transporter (NET) and vesicular monoamine transporter 2 (VMAT2) in the right and left hippocampus of socially isolated adult male rats during 12 weeks by Western blot analysis. RESULTS: Chronic isolation stress reduced norepinephrine content in the right hippocampus. No changes were observed in protein levels of DBH and NET in the right hippocampus, whereas expression of this norepinephrine synthetizing enzyme and transporter were elevated in the left hippocampus. On the other hand, chronic isolation stress caused reduction of VMAT2 protein in the right hippocampus. CONCLUSION: Our results reveale not only the lateralization of stress regulatory system but they also show that long-term isolation stress produces right-left asymmetry of the hippocampus norepinephrine, different regulation of the catecholamines synthesis and reuptake.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.rightsrestrictedAccess
dc.sourceNeuroendocrinology Letters
dc.subjecthippocampusen
dc.subjectchronic stressen
dc.subjectright-left asymmetryen
dc.subjectcatecholaminesen
dc.subjectenzymesen
dc.subjectratsen
dc.titleHippocampal asymmetry in expression of catecholamine synthesizing enzyme and transporters in socially isolated ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage635
dc.citation.issue6
dc.citation.other33(6): 631-635
dc.citation.rankM23
dc.citation.spage631
dc.citation.volume33
dc.identifier.pmid23160224
dc.identifier.rcubconv_1600
dc.identifier.scopus2-s2.0-84871074347
dc.identifier.wos000312175300012
dc.type.versionpublishedVersion


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